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OCR: de it The availability of synthetic CRH has m ons about possible to answer several classical quest The effects hypothalamic-pituitary-adrenal control. cortisol, of CRH on the pituitary are inhibited by ck effect thus confirming a direct pituitary feedba een shown (Fig. 1.23). ADH, which previously had b shown to to have CRH-like activity, has now beer ngs, may bepotentiate CRH action, and in some sett ulator of even more important than CRF as a stin the ACTH release. An important element ir ion by negative feedback control of ACTH secre this cortisol is the striking inhibitory effect o CRH and steroid on the synthesis and secretion of ADH. See also: · Adrenal Cortex Physiology